精简下面表达:Existing protein function prediction methods integrate PPI networks and multivariate bioinformatics data to improve the performance of function prediction. By combining multivariate information, the interactions between proteins become diverse. Different interactions’ functions in functional prediction are various. Combining multiple interactions simply between two proteins can effectively reduce the effect of false negatives and increase the number of predicted functions, but it can also increase the number of false positive functions, which contribute to nonobvious enhancement for the overall functional prediction performance. In this article, we have presented a framework for protein function prediction algorithms based on PPI network and semantic similarity with the addition of protein hierarchical functions to them. The framework relies on diverse clustering algorithms and the calculation of protein semantic similarity for protein function prediction. Classification and similarity calculations for protein pairs clustered by the functional feature are more accurate and reliable, allowing for the prediction of protein function at different functional levels from different proteomes, and giving biological applications greater flexibility.The method proposed in this paper performs well on protein data from wine yeast cells, but how well it matches other data remains to be verified. Yet until now, most unknown proteins have only been able to predict protein function by calculating similarities to their homologues. The predictions result of those unknown proteins without homologues are unstable because they are relatively isolated in the protein interaction network. It is difficult to find one protein with high similarity. In the framework proposed in this article, the number of features selected after clustering and the number of protein features selected for each functional layer has a significant impact on the accuracy of subsequent functional predictions. Therefore, when making feature selection, it is necessary to select as many functional features as possible that are important for the whole interaction network. When an incorrect feature was selected, the prediction results will be somewhat different from the actual function. Thus as a whole, the method proposed in this article has improved the accuracy of protein function prediction based on the PPI network method to a certain extent and reduces the probability of false positive prediction results.
时间: 2023-03-19 12:23:13 浏览: 142
本文提出了一种基于PPI网络和语义相似性,加上蛋白质分层功能的蛋白质功能预测算法框架,对酒葡萄酵母细胞的蛋白质数据表现出良好的效果,但其他数据的效果如何仍有待验证。此外,该框架中的功能特征选择的数量以及每个功能层中蛋白质特征的选择量,对于后续功能预测的准确度有很大影响。因此,在进行特征选择时,必须尽可能选择对整个交互网络重要的多种功能特征,从而提高蛋白质功能预测的准确性,减少错误预测的概率。
相关问题
Reliability and Maintainability Simulation involves a large number of random variables. The use of dynamic arrays will greatly improve the efficiency of simulation and the scale of problem solving. Please design Vector. This problem requires the implementation of a vector class template, which can realize the storage and access of data. (1) [] operator can only access the existing elements. (2) The add method can automatically expand the internal storage space when accessing. Note that the behavior of this vector is different from that of std:: vector. Function interface definition: template <class T> class Vector { ... }
Sure, here's the code for the Vector class template that meets the requirements you specified:
```c++
template <class T>
class Vector {
public:
Vector() : data(nullptr), size(0), capacity(0) {}
~Vector() { delete[] data; }
T& operator[](int index) { return data[index]; }
void add(T value) {
if (size == capacity) {
reserve(capacity == 0 ? 1 : capacity * 2);
}
data[size++] = value;
}
void reserve(int newCapacity) {
T* newData = new T[newCapacity];
for (int i = 0; i < size; ++i) {
newData[i] = data[i];
}
capacity = newCapacity;
std::swap(data, newData);
delete[] newData;
}
int getSize() const { return size; }
private:
T* data;
int size;
int capacity;
};
```
The Vector class template has the following features:
- An empty constructor that initializes the data pointer to `nullptr`, the size and capacity to 0.
- A destructor that deallocates the data array.
- An `operator[]` that returns a reference to the element at the specified index.
- An `add` method that appends the specified element to the end of the data array. If the array is full, it calls the `reserve` method to increase the capacity.
- A `reserve` method that resizes the data array to the specified capacity. It allocates a new array, copies the existing elements to it, swaps the pointers and deallocates the old array.
- A `getSize` method that returns the current size of the data array.
Note that the behavior of this Vector class may differ from that of std::vector in terms of performance and exception guarantees. Therefore, it should be used with caution and tested thoroughly for reliability and maintainability in the context of your simulation.
FWTools Shell FAILURE: Unable to open existing output datasource `C:\Users\L\Desktop\Data\data.txt'.
FWTools Shell是一个基于GDAL/OGR库的命令行工具,用于处理地理空间数据。它提供了一系列的命令和功能,可以进行数据格式转换、投影转换、数据查询、空间分析等操作。
在你提供的错误信息中,"FAILURE: Unable to open existing output datasource `C:\Users\L\Desktop\Data\data.txt'",这个错误提示表明FWTools Shell无法打开指定的输出数据源`C:\Users\L\Desktop\Data\data.txt'。可能的原因包括文件路径错误、文件不存在或者没有足够的权限来访问该文件。
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