This approach is justified given the comparable auto-HCT outcomes before and after 2018 (data not shown). Comparison between CAR-T and auto-HCT was made using propensity score matching as well. Although the effect on disease relapse/progression and mortality was directionality consistent with the primary analysis,itwasnotstatisticallysignificant. This subset analysis reduced the sample size, which likely affected the power to detect statistical significance. The observed difference was mainly observed in patients with $2 prior lines of treatment. This cutoff was used for subgroup analysis, given the implications in clinical practice. Although lack of statistical significance in patients with ,2 prior lines of treatment warrants further attention and ideally prospective trials in that group, the small number of patients in this subgroup analysis limits our ability for making a strong conclusion, particularly because we did not observeaninteraction(effectmodification) between the number of prior treatment lines and treatment modality and outcomes. Patients in the CAR-T group were more heavily pretreated and it is possible that the CAR-T may show improved efficacy in patients with fewer lines of prior treatment Last, we only included patients treated with axi-cel to reduce the heterogeneity given the small number of patients treated with tisa-cel in the registry, fulfilling eligibility criteria for this study at the time of the analysis.翻译

鉴于2018年前后自体造血干细胞移植(auto-HCT)的结果可比(未显示数据)，这种方法是合理的。CAR-T和auto-HCT之间的比较也是使用倾向性评分匹配进行的。尽管对于疾病复发/进展和死亡的影响与主要分析的方向一致，但在统计学上并不显著。这种亚组分析减小了样本量，可能影响了检测统计学显著性的能力。观察到的差异主要发生在先前接受过两种以上治疗方案的患者中。鉴于其在临床实践中的意义，我们使用了该截断值进行亚组分析。尽管在先前接受过两种治疗方案以下的患者中缺乏统计学显著性，值得进一步关注，并最好进行该组别的前瞻性试验，但该亚组分析中患者数量较少限制了我们得出强有力结论的能力，特别是因为我们没有观察到先前治疗方案次数与治疗方式及结果之间的相互作用(效应修饰)。CAR-T组中的患者接受过更多的预处理，CAR-T在先前接受较少治疗方案的患者中可能显示出更好的疗效。最后，我们只纳入接受axi-cel治疗的患者，以减少因登记处中接受tisa-cel治疗的患者数量较少而引起的异质性，同时满足该研究在分析时的入选标准。

相关问题

When using the 3200 Hz or 1600 Hz output data rate, the LSB of the output data-word is always 0. When the data is right justified, the LSB corresponds to Bit D0 of the DATAx0 register; when the data is left justified, the LSB corresponds to Bit D3 of the DATAx0 register.这句话是什么意思

这句话是在描述某种设备或芯片的输出数据格式。其中，3200 Hz 或 1600 Hz 是指设备输出数据的采样率，也就是每秒钟输出多少个数据点。LSB 是指数据中的最低有效位（Least Significant Bit），在这里描述的是输出数据的最后一位。这句话的意思是，当输出数据采用3200 Hz或1600 Hz采样率时，输出数据的最后一位（即最低有效位）始终为0。当数据是右对齐时，LSB对应于DATAx0寄存器的位D0；当数据是左对齐时，LSB对应于DATAx0寄存器的位D3。

Q21: Which of the following is a valid user-defined output stream manipulator header? a. ostream& tab( ostream& output ) b. ostream tab( ostream output ) c. istream& tab( istream output ) d. void tab( ostream& output ) Q22: What will be output by the following statement? cout << showpoint << setprecision(4) << 11.0 << endl; a. 11 b. 11.0 c. 11.00 d. 11.000 Q23: Which of the following stream manipulators causes an outputted number’s sign to be left justified, its magnitude to be right justified and the center space to be filled with fill characters? a. left b. right c. internal d. showpos Q24: Which of the following statements restores the default fill character? a. cout.defaultFill(); b. cout.fill(); c. cout.fill( 0 ); d. cout.fill( ' ' ); Q25: When the showbase flag is set: a. The base of a number precedes it in brackets. b. Decimal numbers are not output any differently. c. "oct" or "hex" will be displayed in the output stream. d. Octal numbers can appear in one of two ways. Q26: What will be output by the following statements? double x = .0012345; cout << fixed << x << endl; cout << scientific << x << endl; a. 1.234500e-003 0.001235 b. 1.23450e-003 0.00123450 c. .001235 1.234500e-003 d. 0.00123450 1.23450e-003 Q27: Which of the following outputs does not guarantee that the uppercase flag has been set? a. All hexadecimal numbers appear in the form 0X87. b. All numbers written in scientific notation appear the form 6.45E+010. c. All text outputs appear in the form SAMPLE OUTPUT. d. All hexadecimal numbers appear in the form AF6. Q28: Which of the following is not true about bool values and how they're output with the output stream? a. The old style of representing true/false values used -1 to indicate false and 1 to indicate true. b. A bool value outputs as 0 or 1 by default. c. Stream manipulator boolalpha sets the output stream to display bool values as the strings "true" and "false". d. Both boolalpha and noboolalpha are “sticky” settings.

A21: a. ostream& tab( ostream& output ) is a valid user-defined output stream manipulator header.

A22: c. 11.00 will be output by the statement.

A23: c. internal is the stream manipulator that causes an outputted number’s sign to be left justified, its magnitude to be right justified and the center space to be filled with fill characters.

A24: d. cout.fill(' ') restores the default fill character, which is a space.

A25: c. "oct" or "hex" will be displayed in the output stream when the showbase flag is set.

A26: b. 1.23450e-003 and 1.23450e-003 will be output by the statements.

A27: d. All hexadecimal numbers appearing in the form AF6 does not guarantee that the uppercase flag has been set.

A28: a. The old style of representing true/false values used -1 to indicate false and 1 to indicate true is not true. False is represented by 0 and true is represented by any non-zero value.