一个中介有若干房源，信息包括房屋编号、房屋地址、业主名称、联系方式、月租金；租赁信息包括房屋编号、承租人、承租开始时间、结束时间；请设计相关类和程序实现房源信息的添加、修改和查询功能以及房屋租赁的管理。

根据题目需求，可以设计以下类：

1. House：房源类，包括属性编号、地址、业主名称、联系方式和月租金，以及方法用于设置和获取这些属性值；

2. Lease：租赁类，包括属性房屋编号、承租人、承租开始时间和结束时间，以及方法用于设置和获取这些属性值；

3. Agency：中介类，包括属性房源列表和租赁列表，以及方法用于添加、修改和查询房源信息，以及管理房屋租赁。

下面是一个示例程序实现：

class House:
    def __init__(self, number, address, owner_name, contact, rent):
        self.number = number
        self.address = address
        self.owner_name = owner_name
        self.contact = contact
        self.rent = rent
        
    def set_number(self, number):
        self.number = number
        
    def set_address(self, address):
        self.address = address
        
    def set_owner_name(self, owner_name):
        self.owner_name = owner_name
        
    def set_contact(self, contact):
        self.contact = contact
        
    def set_rent(self, rent):
        self.rent = rent
        
    def get_number(self):
        return self.number
        
    def get_address(self):
        return self.address
        
    def get_owner_name(self):
        return self.owner_name
        
    def get_contact(self):
        return self.contact
        
    def get_rent(self):
        return self.rent


class Lease:
    def __init__(self, house_number, tenant, start_date, end_date):
        self.house_number = house_number
        self.tenant = tenant
        self.start_date = start_date
        self.end_date = end_date
        
    def set_house_number(self, house_number):
        self.house_number = house_number
        
    def set_tenant(self, tenant):
        self.tenant = tenant
        
    def set_start_date(self, start_date):
        self.start_date = start_date
        
    def set_end_date(self, end_date):
        self.end_date = end_date
        
    def get_house_number(self):
        return self.house_number
        
    def get_tenant(self):
        return self.tenant
        
    def get_start_date(self):
        return self.start_date
        
    def get_end_date(self):
        return self.end_date


class Agency:
    def __init__(self):
        self.house_list = []
        self.lease_list = []
        
    def add_house(self, house):
        self.house_list.append(house)
        
    def modify_house(self, number, address=None, owner_name=None, contact=None, rent=None):
        for house in self.house_list:
            if house.get_number() == number:
                if address is not None:
                    house.set_address(address)
                if owner_name is not None:
                    house.set_owner_name(owner_name)
                if contact is not None:
                    house.set_contact(contact)
                if rent is not None:
                    house.set_rent(rent)
                return True
        return False
    
    def search_house(self, number=None, address=None, owner_name=None, contact=None, rent=None):
        result = []
        for house in self.house_list:
            if (number is None or house.get_number() == number) and \
               (address is None or house.get_address() == address) and \
               (owner_name is None or house.get_owner_name() == owner_name) and \
               (contact is None or house.get_contact() == contact) and \
               (rent is None or house.get_rent() == rent):
                result.append(house)
        return result
    
    def lease_house(self, house_number, tenant, start_date, end_date):
        lease = Lease(house_number, tenant, start_date, end_date)
        self.lease_list.append(lease)
        
    def terminate_lease(self, house_number, tenant):
        for lease in self.lease_list:
            if lease.get_house_number() == house_number and lease.get_tenant() == tenant:
                self.lease_list.remove(lease)
                return True
        return False
    
    def search_lease(self, house_number=None, tenant=None):
        result = []
        for lease in self.lease_list:
            if (house_number is None or lease.get_house_number() == house_number) and \
               (tenant is None or lease.get_tenant() == tenant):
                result.append(lease)
        return result

使用示例：

# 创建中介对象
agency = Agency()

# 添加房源
house1 = House(1, "北京市海淀区", "张三", "13812345678", 2000)
house2 = House(2, "北京市朝阳区", "李四", "13987654321", 2500)
agency.add_house(house1)
agency.add_house(house2)

# 修改房源信息
agency.modify_house(1, address="北京市西城区", rent=2200)

# 查询房源信息
result = agency.search_house(owner_name="李四")
for house in result:
    print("编号：{}，地址：{}，业主：{}，联系方式：{}，月租金：{}".format(
        house.get_number(), house.get_address(), house.get_owner_name(), house.get_contact(), house.get_rent()))

# 租赁房屋
agency.lease_house(2, "王五", "2021-10-01", "2022-09-30")

# 终止租赁
agency.terminate_lease(2, "王五")

# 查询租赁信息
result = agency.search_lease(house_number=1)
for lease in result:
    print("房屋编号：{}，承租人：{}，开始时间：{}，结束时间：{}".format(
        lease.get_house_number(), lease.get_tenant(), lease.get_start_date(), lease.get_end_date()))