通俗翻译Interactions with macrophages in liver metastases were found to drive T cell killing in a Fas-depen- dent manner. Interestingly, this effect was overcome in preclini- cal models via liver-directed radiotherapy—which eliminated these immunosuppressive macrophages and consequently reduced T cell siphoning. Given that patients with liver metas- tasis were also found to have reduced T cell numbers, diversity, and function, these results may have important implications for strategies to improve immunotherapy efficacy for this patient cohort

这项研究发现，在肝转移瘤中，巨噬细胞与T细胞的相互作用以Fas依赖的方式驱动T细胞的杀伤作用。有趣的是，在临床前模型中，通过肝向放疗，这种影响被克服了——这消除了这些免疫抑制性巨噬细胞，从而减少了T细胞的“流失”。鉴于肝转移瘤患者也发现T细胞数量、多样性和功能的减少，这些结果可能对改善这类患者的免疫治疗效果的策略具有重要意义。