In this study we apply methods to determine the tendency for thrombus formation in different central venous catheters (CVC) models associated with flow rate variation. To calculate the thrombogenic potential, we proposed a new numerical model of the platelet lysis index (PLI) equation. To compare the results of PLI and flow rate in different models of catheters, numerical calculations were performed on three different tips of CVC. The results showed that the PLI increases as a power function of the flow rate independent of the type of CVC. This study evidenced that the higher the blood flow rate used in the catheter, the greater the potential for thrombus formation. The PLI computed at the catheter outlet presented higher values when compared to the values computed at the vein outlet indicating that the blood flow through the CVC arterial lumen presents a proportionally larger thrombogenic potential when compared to the blood flow that leaves the vein towards the atrium. This finding may have consequences for clinical practice, since there is no specific flow value recommended in the catheter when the hemodialysis machine is turned on, and with this equation it was possible to demonstrate the thrombogenic potential that the flow rate can possibly offer.
时间: 2023-07-02 07:20:51 浏览: 101
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本研究应用方法,确定不同中心静脉导管(CVC)型号在流量变化下形成血栓的倾向。为了计算血栓形成潜力,我们提出了一个新的血小板溶解指数(PLI)方程数值模型。为了比较不同型号导管中PLI和流量的结果,我们在三个不同的CVC尖端上进行了数值计算。结果表明,PLI随流量的增加呈幂函数增长,与CVC类型无关。本研究表明,导管中使用的血流速度越高,形成血栓的潜力就越大。当与静脉出口计算的PLI相比时,导管出口计算的PLI值更高,这表明通过CVC动脉腔流动的血液与流向心房的静脉流相比具有更大的血栓形成潜力。这一发现可能对临床实践产生影响,因为在透析机启动时,导管中没有特定的流量值建议,而使用这个方程式可以展示流速可能提供的血栓形成潜力。
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