Log Kp (skin permeation) 这个值越大越好吗?
时间: 2024-04-21 21:27:11 浏览: 293
一般来说,Log Kp (皮肤渗透) 的值越大,药物在皮肤上的渗透性就越强。但是,这并不意味着这个值越大越好。因为过高的皮肤渗透性可能会导致药物在皮肤上过快地吸收和迅速进入血液循环系统,从而增加不良反应的风险。此外,药物的治疗效果也可能因为过快的吸收而降低。因此,药物的皮肤渗透性需要在安全和治疗效果之间进行平衡。
相关问题
Log Kp (skin permeation):-8.34 cm/s这个皮肤渗透性怎么样?
根据常见的Log Kp值范围,-8.34 cm/s的值可以被认为是较低的皮肤渗透性,这意味着该药物在皮肤上的渗透性较弱。这种情况下,可能需要使用其他途径来给药,或者采用其他方法,如提高药物的溶解度、使用渗透增强剂或改变药物的化学结构等方法,来提高药物在皮肤上的渗透性。当然,具体情况需要根据药物的性质和治疗目的进行综合考虑。
As for the liquid water content distributions, the liquid saturations in gas diffusion layers are shown in Fig. 6. For both case1 and case 2, the liquid water appears in the vapor saturation areas which locate between the mid area and cathode outlet area. For both cases, the cathode side exhibits apparent higher liquid water content than anode side does. Moreover, the liquid water accumulates in the porous media under the ribs rather than the gas channels, due to the elimination effects of liquid water in gas channels by convective flows. The maximum value of liquid saturation locates at the edge areas of cathode flow field without coverage by the wavy air channels where the oxygen supply is hindered by both blockage of liquid water in porous media and farther distance for gas permeation. The liquid water content of case 2 shows slightly higher than that of case 1, which is a result of tradeoff between operating temperature and pressure. Increasing temperature alleviates the condensation of water vapor, while the increased back pressure lowers volumetric gas flow rate and enhances liquid water accumulation inside the porous media.
就液水含量分布而言,气体扩散层中的液体饱和度如图6所示。对于case1和case2,液体水出现在蒸汽饱和区,位于中间区域和阴极出口区之间。对于这两种情况,阴极侧表现出明显比阳极侧高的液体水含量。此外,由于液体水在气体通道中被对流流动排除,液体水会积聚在空气通道下的多孔介质中而不是气体通道中。液体饱和度的最大值位于阴极流场的边缘区域,这些区域没有被波浪状的空气通道覆盖,在这里氧气供应受到液体水在多孔介质中的阻塞以及气体渗透的较远距离的双重影响。case2的液体水含量略高于case1,这是操作温度和压力之间的折衷结果。温度的升高减轻了水蒸气的凝结,而增加的背压降低了体积气体流量,增强了多孔介质中的液体水积聚。
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