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第 26 卷 第 5 期
2011 年 10 月
天津科技大学学报
Journal of Tianjin University of Science & Technology
Vol.26 No. 5
Oct. 2011
收稿日期:2011–04–27;修回日期:2011–07–19
作者简介:吕连媛(1985—),女,吉林舒兰人,硕士研究生;通信作者:张黎明,教授,博士,zhlm@tust.edu.cn.
银杏萜内酯 A、B、C 和白果内酯的热特征分析
吕连媛
1
,张黎明
1
,王艳乔
1
,高文远
2
(1. 工业发酵微生物教育部重点实验室,天津科技大学生物工程学院,天津 300457;
2. 天津大学药物科学与技术学院,天津 300072)
摘 要:研究银杏萜内酯 A、B、C 和白果内酯的热特征并探讨鉴定这些化合物的新方法.用热重分析法(TGA)和差示
扫描量热法(DSC)分别对银杏萜内酯 A、B、C 和白果内酯进行热特征分析.所有样品的热重(TG)和微商热重(DTG)
曲线都有各自的谱图特征,其 DSC 曲线的峰形、峰位置和峰值也有特征;银杏萜内酯 A、B、C 的稳定性较差,不能准
确测得其熔点;白果内酯受热稳定,能够测得其熔点.利用 TGA 和 DSC 法容易鉴定银杏萜内酯 A、B、C 和白果内
酯.用 TG-DTG 法对银杏萜内酯 A、B、C 和白果内酯在非等温条件下进行热分解动力学研究,把从 TG-DTG 曲线中
得到的数据和 30 个不同的方程采用 Achar 微分法和
Madhusudanan-Krishnan-Ninan(MKN)积分法对其进行非等温分
解动力学研究,得到动力学参数活化能(E 和指前因子 A)和分解动力学机理及方程.
关键词:热分析;银杏萜内酯;白果内酯
中图分类号:R284.2 文献标志码:A 文章编号:1672-6510(2011)05-0009-04
Analysis of Thermal Characterization of Ginkgolides
A
,
B
,
C and Bilobalide
LÜ Lian-yuan
1
,ZHANG Li-ming
1
,WANG Yan-qiao
1
,GAO Wen-yuan
2
(1. Key Laboratory of Industrial Fermentation Microbiology,Ministry of Education,College of Biotechnology,
Tianjin University of Science & Technology,Tianjin 300457,China;
2. College of Pharmaceutical Science and Technology,Tianjin University,Tianjin 300072,China)
Abstract:Thermal characterization of ginkgolides A,B,C and bilobalide was to be studied and found a new identification
method of these samples. Thermal properties of ginkgolides A,B,C and bilobalide from Ginkgo biloba L. were investigated
by using thermogravimetric analysis(TGA)and differential scanning calorimetry(DSC)techniques. All the samples have
their own mass loss features in TG and DTG curves,the DSC curves of these substances have their own characteristic curvi-
linear types,peak location and peak values. The thermal property of bilobalide is quite stable,and the crystal forms of the
ginkgolides A,B,C are easily changed. It is possible to easily distinguish ginkgolides A,B,C and bilobalide according to
their thermal characteristics. The non-isothermal kinetics of the ginkgolides A,B,C and bilobalide were studied by use o
non-isothermal TG-DTG curves. The non-isothermal kinetics data were analyzed by means of Achar differential method and
Madhusudanan-Krishnan-Ninan(MKN)integral method. The possible reaction mechanisms have been investigated by com-
paring the kinetics parameters.
Keywords:thermal analysis;ginkgolides;bilobalide
银杏(Ginkgo biloba L.)为银杏科(Ginkgoaceae)
银杏属植物,又名白果树、公孙树、鸭脚通,是古生代
二叠纪孑遗植物,被称为裸子植物的“活化石”.银
杏萜内酯化合物是银杏叶中独有的具有特殊分子结
构和显著药理活性的成分,包括二萜内酯和倍半萜内
酯,其中二萜内酯有 5 种,即银杏萜内酯(ginkgolide)
A、B、C、J 和 M(GA、GB、GC、GJ 和 GM),倍半萜内
酯 1 种,即白果内酯(bilobalide,BB),结构式如图
1.银杏萜内酯含量高低,对银杏提取物及其制剂的内
在质量起着重要的作用.目前,国内外学者已对它们