Contents
SECTION I PRINCIPLES OF LABORATORY MEDICINE
1 Clinical Chemistry, Molecular Diagnostics, and
Laboratory Medicine
2 Selection and Analytical Evaluation of Methods—With
Statistical Techniques
3 Clinical Utility of Laboratory Tests
4 Evidence-Based Laboratory Medicine
5 Establishment and Use of Reference Values
6 Preanalytical Variables and Biological Variation
7 Specimen Collection and Processing
8 Quality Management
SECTION II ANALYTICAL TECHNIQUES AND INSTRUMENTATION
9 Principles of Basic Techniques and Laboratory Safety
10 Optical Techniques
11 Electrochemistry and Chemical Sensors
12 Electrophoresis
13 Chromatography and Extraction
14 Mass Spectrometry
15 Enzyme and Rate Analyses
16 Principles of Immunochemical Techniques
17 Nucleic Acid Techniques
18 Microfabrication and Microuidics and eir
Application to Clinical Diagnostics
19 Automation in the Clinical Laboratory
20 Point-of-Care Instrumentation
SECTION III ANALYTES
21 Amino Acids, Peptides, and Proteins
22 Serum Enzymes
23 Enzymes of the Red Blood Cell
24 Tumor Markers
25 Kidney Function Tests
26 Carbohydrates
27 Lipids, Lipoproteins, Apolipoproteins, and Other
Cardiac Risk Factors
28 Electrolytes and Blood Gases
29 Hormones
30 Catecholamines and Serotonin
31 Vitamins and Trace Elements
32 Hemoglobin, Iron, and Bilirubin
33 e Porphyrias and Other Disorders of Porphyrin
Metabolism
34 erapeutic Drugs and eir Management
35 Clinical Toxicology
36 Toxic Metals
SECTION IV MOLECULAR DIAGNOSTICS AND GENETICS
37 Principles of Molecular Biology
38 Genomes and Nucleic Acid Alterations
39 Nucleic Acid Isolation
40 Inherited Diseases
41 Identity Assessment
42 Molecular Methods in Diagnosis and Monitoring of
Infectious Diseases
43 Pharmacogenetics
44 Hematopoietic Malignancies
45 Plasma Nucleic Acids
SECTION V PATHOPHYSIOLOGY
46 Diabetes Mellitus
47 Cardiac Function
48 Kidney Disease
49 Physiology and Disorders of Water, Electrolyte, and
Acid-Base Metabolism
50 Liver Disease
51 Gastric, Pancreatic, and Intestinal Function
52 Bone and Mineral Metabolism
53 Pituitary Function and Pathophysiology
54 e Adrenal Cortex
55 e yroid: Pathophysiology and yroid Function
Testing
56 Reproductive Endocrinology and Related Disorders
57 Pregnancy and Its Disorders
58 Newborn Screening and Inborn Errors of Metabolism
59 Hemostasis
SECTION VI APPENDIX
60 Reference Information for the Clinical Laboratory
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