Surface Plasmon Resonance (SPR) technology is a novel technique developed in the 1990s for detecting the interactions between ligands and analytes on biosensor chips using the principles of SPR. The history of SPR technology dates back to the early 20th century when Wood first observed the SPR phenomenon in optical experiments. Subsequent advancements were made by Fano, Kretschmann, Liedberg, Knoll, and Biacore AB, leading to the commercialization of SPR instruments in 1990.
SPR technology is widely used in real-time analysis to monitor interactions between DNA and proteins, proteins, drugs, nucleic acids, antigens, antibodies, receptors, and ligands in various biological, medical, pharmaceutical, food, environmental, forensic, and drug testing applications. The principle of SPR technology involves the excitation of surface plasmons on a sensor surface, which results in changes in the refractive index as a result of molecular interactions.
Overall, SPR technology offers a convenient and rapid means of studying biomolecular interactions with high sensitivity and specificity, making it a valuable tool in various scientific and medical fields. Its versatility and applicability in a wide range of areas make it an indispensable technology in modern research and industry.
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