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Journal of Cancer 2015, Vol. 6
http://www.jcancer.org
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2015; 6(6): 519-524. doi: 10.7150/jca.11404
Research Paper
High EGFR_1 Inside-Out Activated Inflammation-
Induced Motility through SLC2A1-CCNB2-HMMR-KIF11-
NUSAP1-PRC1-UBE2C
Huilei Zhou
1,*
, Lin Wang
1,*,
, Juxiang Huang
1,*
, Minghu Jiang
2,*
, Xiaoyu Zhang
1
, Liyuan Zhang
1
,
Yangming Wang
1
, Zhenfu Jiang
1
, Zhongjie Zhang
3
1. Biomedical Center, School of Electronic Engineering, Beijing University of Posts and Telecommunications, Beijing, 100876, China
2. Lab of Computational Linguistics, School of Humanities and Social Sciences, Tsinghua University, Beijing, 100084, China
3. College of information, North China University of Technology, Beijing, 100043, China
* Equal contribution
Corresponding author: Lin Wang (Prof. Dr.), Biomedical Center, School of Electronics Engineering, Beijing University of Posts and
Telecommunications, Beijing, 100876, China. Email: wanglin98@tsinghua.org.cn Tel: 8610-13240981826
© 2015 Ivyspring International Publisher. Reproduction is permitted for personal, noncommercial use, provided that the article is in whole, unmodified, and properly cited.
See http://ivyspring.com/terms for terms and conditions.
Received: 2014.12.20; Accepted: 2015.02.20; Published: 2015.04.05
Abstract
48 different Pearson mutual-positive-correlation epidermal growth factor receptor
(EGFR_1)-activatory molecular feedback, up- and down-stream network was constructed from
171 overlapping of 366 GRNInfer and 223 Pearson under EGFR_1 CC ≥0.25 in high lung adeno-
carcinoma compared with low human normal adjacent tissues. Our identified EGFR_1 inside-out
upstream activated molecular network showed SLC2A1 (solute carrier family 2 (facilitated glucose
transporter) member 1), CCNB2 (cyclin B2), HMMR (hyaluronan-mediated motility receptor
(RHAMM)), KIF11 (kinesin family member 11), NUSAP1 (nucleolar and spindle associated protein
1), PRC1 (protein regulator of cytokinesis 1), UBE2C (ubiquitin-conjugating enzyme E2C) in high
lung adenocarcinoma. EGFR_1 inside-out upstream activated terms network includes intracellular,
membrane fraction, cytoplasm, plasma membrane, integral to membrane, basolateral plasma
membrane, transmembrane transport, nucleus, cytosol, cell surface; T cell homeostasis, inflam-
mation; microtubule cytoskeleton, embryonic development (sensu Mammalia), cell cycle, mitosis,
thymus development, cell division, regulation of cell cycle, Contributed--cellular process--Hs cell
cycle KEGG, cytokinesis, M phase, M phase of mitotic cell cycle, estrogen-responsive protein Efp
controls cell cycle and breast tumors growth, cell motility, locomotion, locomotory behavior,
neoplasm metastasis, spindle pole, spindle microtubule, microtubule motor activity, microtu-
bule-based movement, mitotic spindle organization and biogenesis, mitotic centrosome separa-
tion, spindle pole body organization and biogenesis, microtubule-based process, microtubule,
cytokinesis after mitosis, mitotic chromosome condensation, establishment of mitotic spindle
localization, positive regulation of mitosis, mitotic spindle elongation, spindle organization and
biogenesis, positive regulation of exit from mitosis, regulation of cell proliferation, positive regu-
lation of cell proliferation based on integrative GO, KEGG, GenMAPP, BioCarta and disease da-
tabases in high lung adenocarcinoma. Therefore, we propose high EGFR_1 inside-out activated
inflammation-induced motility through SLC2A1-CCNB2-HMMR-KIF11-NUSAP1-PRC1-UBE2C in
lung adenocarcinoma.
Key words: EGFR_1 activated network; inside-out; motility; inflammation;
SLC2A1-CCNB2-HMMR-KIF11-NUSAP1-PRC1-UBE2C
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