MySQLdb.OperationalError: (2002, "Can't connect to server on 'localhost' (10061)")

This error message indicates that the MySQL client is unable to connect to the MySQL server running on the localhost (i.e., the same machine as the client). The error code 10061 specifically indicates that the connection was refused by the server.

There are several possible causes for this error, including:

1. The MySQL server is not running. In this case, you will need to start the MySQL server before attempting to connect to it.

2. The MySQL server is running on a different host or port. By default, MySQL runs on port 3306, but it is possible to change the port number. Check your MySQL configuration to ensure that you are using the correct host and port settings.

3. The MySQL server is not configured to allow remote connections. By default, MySQL is configured to only accept connections from the localhost. If you are attempting to connect to the server from a remote machine, you may need to configure MySQL to allow remote connections.

4. There is a firewall or network issue preventing the client from connecting to the server. Check your firewall settings and network configuration to ensure that the client is able to communicate with the server.

To troubleshoot this issue, you can try the following steps:

1. Verify that the MySQL server is running and accepting connections.

2. Check your MySQL configuration to ensure that you are using the correct host and port settings.

3. Verify that the MySQL server is configured to allow remote connections if you are connecting from a remote machine.

4. Check your firewall settings and network configuration to ensure that the client is able to communicate with the server.

If you are still unable to connect to the MySQL server, you may need to consult the MySQL documentation or seek assistance from a qualified MySQL administrator.