exposure_dat <- ld_clump_local( + dat = df1, + clump_kb = 500, + clump_r2 = 0.2, + clump_p = 1e-5, + bfile = "D:/R-language/MR代码/课题组数据/g1000_eas", + plink_bin = "D:/R-language/R-4.2.2/library/plinkbinr/bin/plink_Windows.exe" + ) PLINK v1.90b6.10 64-bit (17 Jun 2019) www.cog-genomics.org/plink/1.9/ (C) 2005-2019 Shaun Purcell, Christopher Chang GNU General Public License v3 Logging to C:\Users\86131\AppData\Local\Temp\Rtmp8kX5Lf\file3e5474b5111.log. Options in effect: --bfile D:/R-language/MR����/����������/g1000_eas --clump C:\Users\86131\AppData\Local\Temp\Rtmp8kX5Lf\file3e5474b5111 --clump-kb 500 --clump-p1 1e-05 --clump-r2 0.2 --out C:\Users\86131\AppData\Local\Temp\Rtmp8kX5Lf\file3e5474b5111 14188 MB RAM detected; reserving 7094 MB for main workspace. Allocated 5320 MB successfully, after larger attempt(s) failed. Error: Failed to open D:/R-language/MR����/����������/g1000_eas.bed. Error in file(file, "rt") : cannot open the connection In addition: Warning message: In file(file, "rt") : cannot open file 'C:\Users\86131\AppData\Local\Temp\Rtmp8kX5Lf\file3e5474b5111.clumped': No such file or directory

It seems like there is an error in the code related to file paths. Specifically, the error message says that the program failed to open the file "D:/R-language/MR����/����������/g1000_eas.bed". This could be due to incorrect file path or missing file. Additionally, there is a warning message that says "cannot open file 'C:\Users\86131\AppData\Local\Temp\Rtmp8kX5Lf\file3e5474b5111.clumped': No such file or directory". This could be due to the program not finding the output file at the specified location.